Oral dissolving strips
FlashRelease™ Technology
Not all orally dissolvable strips are created equal. There are many factors that influence bioavailability, dissolution time, and user experience.
Our FlashRelase™ has the following properties:
Area – 25 mm x 20 mm – 45 mm
Thickness – 0.08 mm – 0.12 mm
Structure – single layer
Polymers – pullulan, hydroxypropyl methylcellulose, cellulose
Plasticizers – Vegetable glycerin, polyethylene glycol
Saliva stimulants – Citric acid, malic acid
Composition
The orally soluble strips contain only natural ingredients and are free from fillers, sugar, gluten, soy, and allergens.
Polymers such as pullulan, hydroxypropyl methylcellulose (HMPC), and pectin
Softeners such as vegetable glycerin
Saliva-stimulating ingredients such as citric acid
Natural colors, sweeteners, flavorings
Active ingredients
Each strip contains its own nutrients or active ingredients, flavorings, sweeteners, and other ingredients. Our FlashRelease™ strip is small, thin, single-layered, and combines polymers and plasticizers in specific ratios that promote film structure and facilitate rapid dissolution. The addition of a saliva-promoting component further shortens the dissolution time.
What are orally dissolvable strips?
Orally dissolvable strips are a new dosage form. The development of polymer films has made it possible to improve bioavailability and customer compliance when taking dietary supplements orally. The anatomical and physiological characteristics of the oral mucosa, such as the presence of smooth muscles with high blood flow and easy accessibility, make it a favorable route for the administration of nutrients [1].
Advantages of orally soluble strips
A new dosage form
Capsules and tablets become unnecessary
No water required
Fast-acting
Easily metabolized
Only the necessary ingredients
Conventional forms of dietary supplements such as tablets and capsules are not ideal. The user must take them, wait until they have dissolved, wait until the nutrients have dissolved and passed through first-pass metabolism. Only then can the user benefit from the nutrients.
Challenges remain in pediatrics, geriatrics, and other areas where swallowing tablets is difficult or rejected. Dietary supplements in the form of liquids, drinks, or drink mixes have the disadvantage of requiring water, having uneven dosages, containing sugar and other unnecessary ingredients, being packaged in bulky containers that are difficult to carry around, and being easy to spill.
Clinical advantages over other dosage forms
Consumers prefer orally dissolvable strips because of their appealing form and ease of administration [4]. In addition, orally dissolvable films are extremely useful for pediatric, geriatric, and psychiatric patients, as well as pets, as they are easy to administer and avoid the risk of choking, ensuring the safety of consumers and pets.
Fast-acting
High bioavailability
Easy to take (no choking hazard)
Extremely convenient (each strip is individually packaged)
Discreet intake of your daily vitamins
Can be used without water
Easy to use with children, the elderly, and pets
Bypasses the gastrointestinal tract, increasing bioavailability
Bioavailability study compared to other dosage forms
Oral dissolving strips can increase bioavailability due to their rapid dissolution in saliva without water and the rapid absorption of nutrients through the oral mucosa [5].
A comparative dissolution study was conducted between orally soluble strips, powdered drugs/nutrients, and a tablet to investigate the success of the optimized orally soluble strips in increasing the dissolution rate.
The optimized orally soluble strip (F1) showed a significant increase in dissolution rate and degree of dissolution compared to the dissolution of pure powder and the tablet. This figure shows that 96.02% of the optimized strip (F1) dissolved within just 10 minutes, compared to 10.04% and 26.37% of the pure powder and tablet, respectively. The degree of dissolution of the strip after 10 minutes was more than 9.5 times and 3.6 times higher than that of the active ingredient released from the pure powder and tablet, respectively [5]. ** PX is paroxetine.
Study on the bioavailability of orally and intravenously administered melatonin
This crossover cohort study investigated the pharmacokinetics of orally and intravenously administered melatonin in healthy male subjects. Oral melatonin was rapidly absorbed, and Tmax was reached after 41 minutes. Cmax and AUC varied greatly between subjects. The elimination half-lives after oral and intravenous melatonin administration were 54 minutes and 39 minutes, respectively. The bioavailability of oral melatonin was only 3%, but significant differences were observed between subjects [7].
Permeation study in comparison to other dosage forms
Numerous permeability studies have shown how important it is to choose a suitable mucous membrane, given that the cheek mucosa of many laboratory animals, such as rabbits and rats, is completely covered with keratin [6]. The cheek mucosa of chickens, on the other hand, is considered the best alternative because it resembles the non-keratinized and thin oral mucosa of humans. The permeation of the optimized strip and the pure powder through freshly harvested chicken cheek mucosa was investigated [5].
The optimized strip (F1) showed a significant increase in permeation rate and degree of permeation compared to the pure powder, as shown in Figure 6. The flow values (J) were determined, and there was a significant difference (p-value < 0.001) between the optimized strip (F1) (85.00 _g/h/cm2) compared to the pure powder (26.66 _g/h/cm2) [5].
References
https://www.sciencedirect.com/science/article/abs/pii/S0141813014004875
https://journals.sagepub.com/doi/10.1177/00220345890680091101
https://www.sciencedirect.com/science/article/abs/pii/S016836590900426X
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957312/
https://pubmed.ncbi.nlm.nih.gov/34834284/
https://sites.ualberta.ca/~csps/JPPS1(1)/A.Shojaei/buccalreview.htm
https://pubmed.ncbi.nlm.nih.gov/26893170
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